Archive for August, 2011

Alzheimer’s: How a worldwide epidemic remains a mystery while hidden in plain sight

August 21, 2011

Alzheimer’s Disease: A Worldwide Epidemic Remains a Mystery While Hidden in Plain SIght!
August 20, 2011,

The cause of this worldwide epidemic remains cloaked in mystery, while affecting the lives of at least 50 million people around the world. Although the disease is widely recognized, its origin is still debated and speculation over the cause is published almost daily in various media, and in peer reviewed medical journals. While the media report almost daily, of newly discovered causes, the real cause, mysteriously, remains disregarded. However, while also remaining in plain sight, in facilities in U.S., are 5 million patients, victims of the epidemic.

Migratory water fowl are the vital key to the mystery of the epidemic; they carry the causative agent (Helicobacter pylori ) in their intestines. Since the dawn of history, man has been fascinated by the disappearance and return of birds. The migratory phenomenon is not unique to birds, it is part of the ongoing evolution of natural forces which affect all species on earth in one way or another. We already know that the transfer of disease between man and nature’s birds and animals cause many serious infectious diseases.

It has taken 29 years for the world to fully appreciate the great discovery of Helicobacter pylori (HP), a Class-1 Carcinogenic bacterium. This bacterium, when ingested from our drinking water is known to cause gastritis, peptic ulcers and gastric cancer, along with several other conditions and diseases. The hidden, but in plain sight mystery, is that HP, when ingested, finds a home in the acid medium of the human stomach and colonizes in the stomach wall, often for life, with minimal symptoms. The colonizing bacteria, who have flagellae, and can move about freely, establish a process resulting in a chronic infectious inflammation in the stomach (gastritis) lining. This in turn initiates a process which stimulates uninfected cells in the stomach walls, to produce amyloid, as a protective reaction.

Amyloid has been known to clinicians for many decades and has long been related to chronic infection or inflammation somewhere in the human body. Amyloid consists of many proteins and is a known product of genes which can produce up to 60 different proteins when stimulated by infection. Once the amyloid cycle begins, tiny bits of protein enter the bloodstream and develop into amyloid when deposited in organs such as liver, spleen, especially kidneys, brain and even into the walls of blood vessels.

The amyloid proteins, formed in response to chronic infection, circulate in the blood stream as tiny droplets (oligomers), transforming into amyloid fibrils and plaques when deposited in brain tissue, becoming the cause of Alzheimer’s disease. The accumulation of amyloid takes place over long periods of time, and often results in early Alzheimer’s, not always recognized in patients as young as 40-50 years of age. In lesser developed countries, with a high rate of HP infection, even children as early as age 2 are infected. The presence of HP infection can be detected by an antibody blood test or a breath test, or gastroscopy with biopsy. New methods of PET scanning (x-ray). spinal taps and eye scanning may also be used to find evidence of Alzheimer’s, but much more expensive, and do not provide any more information than the blood or breath tests.

The great mystery of HP infection is that it is simply due to bird droppings into our reservoirs. AD is not due to kissing, hugging, dental plaque, food (rarely), or from brain cell malfunction, or prevented by drinking alcohol, wine , exercise or any other means except clean water. HP in our drinking water water, contaminated by droppings from migratory water fowl, is the cause of Alzheimer’s disease. AD is not due to aging, heredity or the myriad of causes reported so often in the media as breakthroughs. HP has been found in water supplies worldwide by University researchers from Penn State University, MIT, research facilities in other countries, as well as the EPA . Migratory water fowl carry HP endemically in their intestines. Their droppings, average one pound a day per goose, into reservoirs and other sources of drinking water, are the cause of human infection. Although HP infection is epidemic and although it is labeled as a Class-1 carcinogen, causing stomach cancer and probably other cancers, the EPA, the government agency that oversees the safety of our drinking water, has not required our drinking water to be be routinely tested for HP pollution.

The key to the mystery of the epidemic is HP. By causing chronic infectious gastritis, usually with minimal or no symptoms, HP infection has eluded detection by physicians. Amyloid is the body’s response to chronic infection. Before 1940, we did not have antibiotics to eradicate infection, and Amyloidosis was a commonly recognized condition with deposits of amyloid appearing in liver, kidneys, spleen, brain and skin.

Unfortunately, there are no medications to free patients from the deadly grip of Alzheimer’s. However, we do have the knowledge to prevent Alzheimer’s by regularly testing and treating our water supplies, for HP. Individuals can elect to have either blood or breath tests to determine if HP infection exists. Regular testing for HP should start at young ages and repeated every few years. Early treatment with antibiotics can possibly halt the production of Amyloid. This approach should prevent Alzheimer’s. It is already underway in Japan, which has been suffering from a very high incidence of Gastric Cancer, a result of HP infection. We must demand government accountability and require EPA to fulfill their mandated responsibilities and carry out regular testing and treatment of our drinking water.

“Clean water has saved more lives than all the pharmaceuticals ever produced”, was written by H.McKinnell, the former CEO of Pfizer who also believes that we need more emphasis on prevention, rather than treatment (published in his book “A Call to Action”). Alzheimer’s, Gastritis, Gastric Cancer and Peptic Ulcers can be prevented. We have many dedicated organizations. They need to clamor for action. The cause of Alzheimer’s is in plain sight, in our reservoirs, ponds and wells.

Written by Sidney W. Rosen MD MPH FACP FACG, based on research done over the past few years Every fact stated in this article is supported by scientifically researched studies from around the world. Alzheimer’s is a worldwide epidemic. and is escalating. We need to use new ideas that are bold and transformative. This article was written for that purpose. Failure to institute preventive measures
to contain this pandemic, will result in an increasing strain on budgets and caregivers in our country as well as worldwide.

Sidney W. Rosen MD MPH FACP FACG
10 North MAin ST.
Fall River, MA. 02722
Callsid@aol.com or swrosen@ me.com

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A Worldwide Epidemic Remains a Mystery while Hidden in Plain Sight!

August 17, 2011

A mystery epidemic, cloaked in a fog of confusion, has already doomed the lives of at least 50 million people around the world. Although the disease is widely recognized, its origin is reported as unknown and yet speculation over the cause is published almost daily in various media, and in peer-reviewed medical journals. While the media report almost daily, of newly discovered causes, the real cause mysteriously, remains disregarded. However, while remaining in plain sight, in facilities in U.S., are 5 million patients, victims of the epidemic.

Rational scientific reasoning, seems to have been replaced by dictatorial influence over researchers trying to solve this mystery. As a result, our great university and hospital research laboratories are not actively engaging in research for preventive measures but rather, are striving to develop new methods of treatment. So far, the effort to discover new effective medications to treat patients with this epidemic illness, has been an admitted failure and hopes for success are now projected 10-15 years into the future. While genomic research has uncovered a few inherited syndromes, the extremely complicated functions and interactions of genes will require years to discover the understanding necessary to use for diagnosis and treatment of disease. Researchers active in the field estimate another 10-15 years.

Migratory water fowl are the vital key to the mystery of the epidemic, since they carry the causative agent in their intestines. Since the dawn of history, man has been fascinated by the disappearance and return of birds. The migratory phenomenon is not unique to birds, it is part of the ongoing evolution of natural forces which affect all species on earth in one way or another. We already know that the transfer of disease between man and nature’s birds and animals cause many serious infectious diseases.

It has taken 29 years for the world to fully appreciate the full meaning of the great discovery of Helicobacter pylori (HP), a Class-1 Carcinogenic bacterium. This motile bacterium, when ingested from our drinking water is known to cause gastritis, peptic ulcer and gastric cancer along with several other diseases. The hidden, but in plain sight mystery, is that HP, when ingested, finds a home in the human stomach and colonizes the stomach wall, often for life, with minimal symptoms. The colonizing bacteria, who have flagellae, and are motile, result in chronic infectious inflammation in the stomach (gastritis) lining, which in turn stimulates uninfected cells, to produce amyloid.

Amyloid has been known to clinicians for many decades and has long been related to chronic infection or inflammation in the human body. Amyloid consists of many proteins. Once the amyloid cycle begins, the tiny bits enter the bloodstream and result in amyloid deposits in other organs such as liver, spleen, especially kidneys, brain and even into the walls of blood vessels.
The amyloid proteins, formed in response to chronic infection, circulate in the blood stream as tiny droplets transforming into amyloid. These droplets become the amyloid fibrils and plaques in brain tissue, the cause of Alzheimer’s disease. The accumulation of amyloid takes place over long periods of time, and often results in early Alzheimer’s, not always recognized in patients as young as 40-50 years of age. In lesser developed countries, with a high rate of HP infection, even children as early as age 2 are infected. The presence of HP infection can be detected by an antibody blood test or a breath test, or gastroscopy with biopsy. New methods of PET scanning (x-ray). spinal taps and eye scanning may also be used to find evidence of Alzheimer’s, but much more expensive, and do not provide any more information than the blood or breath tests.

The great mystery of HP infection is that it is simply due to bird droppings in our reservoirs. It is not due to kissing, hugging, dental plaque, food (rarely), or from brain cell malfunction. It is present in water that has been contaminated by droppings from migratory water fowl. Alzheimer’s disease (HP), is the result of HP infection. It is not due to aging, heredity or the myriad of causes reported so often in the media as breakthroughs. HP has been found in water supplies worldwide by University researchers from Penn State University, MIT, research facilities in other countries, as well as the EPA . Migratory water fowl carry HP endemically in their intestines. Their droppings into reservoirs and other sources of drinking water are the cause of human infection. Although HP infection is epidemic and although it is labeled as a Class-1 carcinogen, causing stomach cancer and probably other cancers, the EPA, the government agency that oversees the safety of our drinking water, has not required our drinking water to be routinely tested for HP pollution.

The key to the mystery of the epidemic is HP causing chronic infectious gastritis, usually with minimal or no symptoms, and which has eluded clinical detection by physicians. Amyloid is the body’s response to chronic infection. Before 1940, we did not have antibiotics to eradicate infection, and Amyloidosis was a commonly recognized condition with deposits of amyloid in liver, kidneys, spleen, brain and skin.

Unfortunately, we do not yet have any medication to free patients from the deadly grip of Alzheimer’s. However, we do have the knowledge to prevent Alzheimer’s by regularly testing and treating our water supplies, for HP. Individuals can elect to have either blood or breath tests to determine if HP infection exists. Regular testing for HP should start at young ages and repeated every few years. Early treatment with antibiotics can possibly halt the production of Amyloid. This approach should prevent Alzheimer’s. It is already underway in Japan, which has been suffering from a very high incidence of Gastric Cancer, a result of HP infection. We must, therefore, demand government accountability and require that EPA fulfills their mandated responsibilities and carry out regular testing and treatment of our drinking water.

“Clean water has saved more lives than all the pharmaceuticals ever produced”, was written by H.McKinnell, the former CEO of Pfizer who also believes that we need more emphasis on prevention, rather than treatment (published in his book “A Call to Action”). Alzheimer’s, Gastritis, Gastric Cancer and Peptic Ulcers can be prevented. We have many dedicated organizations. they need to clamor for action. The cause of Alzheimer’s is in plain sight, in our reservoirs, ponds and wells.

Written by Sidney W. Rosen MD MPH FACP FACG, based on research done over the past few years Every fact stated in this article is supported by scientifically researched studies from around the world. Alzheimer’s is a worldwide epidemic. and is escalating. We need to use new ideas that are bold and transformative. This article was written for that purpose. Failure to institute preventive measures
to contain this pandemic, will result in an increasing strain on budgets in our country as well as worldwide.

Sidney W. Rosen MD MPH FACP FACG
10 North Main St.
Fall River, MA. 02722
Callsid@aol.com or swrosen@me.com

HP Contamination and its affect on Alzheimers

August 17, 2011

The International Conference on Alzheimer’s Disease (AD) held in Paris June 2011, had little to report regarding treatment, cure or prevention. The lack of any real progress is disappointing to families and patients with AD.

I have followed the Helicobacter pylori (HP) discovery since 1982, when Dr. Graham, President of the ACG, read the paper from Doctors Warren and MarshaLL, that reported the original discovery and method of culture of HP. They were presented With the Noble prize in Medicine in 1985. The cause of gastritis, peptic ulcers, and cancer of the stomach was confirmed to be HP infection. My continued interest in HP has led me to conclude after many years of research, that the cause of Alzheimer’s disease has been lying in plain sight. Amyloid has been proven to be the sticky substance deposited in the brain, the cause of dementia. We have known for a very long time that chronic infection stimulates a process that creates amyloid. That fact was known long before we had antibiotics, which were developed in the early 1940’s. After the discovery of antibiotics, many chronic infections disappeared. When methods allowing study of the human genome , and special apparatus became available, the structure of the many protein fractions that make up amyloid became the focus of research.

Meanwhile, several universities, such as Penn State, MIT, and even EPA reported that a high percentage of reservoirs were contaminated with HP, but very little interest was generated.
Nevertheless, hidden in plain site, were flocks of migratory fowl living on the surface of our reservoirs and ponds and bringing with them HP. HP has been found by researchers worldwide in the feces of migratory geese. They deposit a pound a day, per goose, of HP bearing feces into our reservoirs.
Authorities have labeled HP as a Class-1 Carcinogen, causing chronic gastritis, peptic ulcers, and cancers of the stomach. Gastritis and ulcers are treated now with antibiotics.

Even though HP is a carcinogen, we still do not test our drinking water for HP which has been demonstrated to be susceptible to chlorine and related products.

I have spoken to authorities at the EPA who advised me that the EPA may be unable to require testing and treatment of our drinking water for a few more years. They cited lack of personnel, money and legal wrangling which has restricted the EPA from carrying out its mandated duties. (NYTimes,February 28, 2010). The consequence of the legal wrangling has interfered with EPA duties. As a result we do not have an effective policy in place to control HP infection.

Our President has recently appointed a 20 person commission to find a solution for prevention and treatment of AD in the next ten years!

The cause of AD results from a chronic infectious gastritis, almost always present with HP infection, often with very few symptoms, but which stimulates non-infected tissue in the stomach wall to produce amyloid. Upon initiation of the process which affects cells surrounding the infected tissues, amyloid begins to discharge tiny droplets of protein into the blood stream. These amyloid precursors may infiltrate into several organs, as well as the brain, where it causes fibrils and plaques of amyloid resulting in AD.
Although, we have less AD than undeveloped countries, we still have 5.4 million patients with AD, at present, and the number is steadily growing. Other countries such as China and Japan have had very high rates of peptic ulcers and stomach cancer and recently started a program to prevent HP infection. We know from many studies, that clean water has saved more lives than pharmaceuticals. We need action by public foundations and Alzheimer’s organizations to compel our agencies to fulfill their duties. Prevention, is by far, the most effective way to control the AD epidemic, and end the fear of families that AD is inevitable and is a disease of heredity and aging. It is neither. It is an infectious disease and preventable.